Publications and presentations

Publications

• 2026

  Impact of the RayDyLyo® device on primary drying efficiency in freeze-drying. White paper, in preparation.

• 2021

  Co-inventor, international patent PCT/EP2021/085429 — Assembly and filling process for the production of needle-less medical devices.

• 2017

  Co-author, Patheon Drug Product Services Global Technology Transfer Policy.

• 2016

  Co-author, Takeda Guidance for QbD implementation in Global PTRDL v1.0 — chapters on QTPP, on CQA, CMA, CFP and CPP, and on design of experiments.

• 2013

  Keldenich J., Denicourt-Nowicki A., Michon C., Agbossou-Niedercorn F. — Preparation of chiral key intermediates of morpholine based neurokinin receptor antagonists by asymmetric allylic alkylation. Tetrahedron, 69 (31), 6424–6430.

• 2011

  Keldenich J., Michon C., Nowicki A., Agbossou-Niedercorn F. — Synthesis of a chiral key intermediate of neurokinin antagonist SSR 240600 by asymmetric allylic alkylation. Synlett, 20, 2939–2942.

• 2007

  Gauvin R., Delevoye L., Ali Hassan R., Keldenich J., Mortreux A. — Well-defined silica-supported rare-earth silylamides. Inorganic Chemistry, 46, 1062–1070.

  Nowicki A., Keldenich J., Agbossou-Niedercorn F. — Highly selective preparation of a chiral quaternary allyl aryl piperidinedione by palladium-catalyzed asymmetric allylation under solid–liquid phase-transfer catalysis. European Journal of Organic Chemistry, 36, 6124–6127.

• 2006

  PhD thesis, awarded with honours — Application of asymmetric catalysis to the synthesis of pharmaceutical intermediates. Referees: Prof. Janine Cossy and Prof. Leon Ghosez.

Conference presentations

• 2026

  A new paradigm in lyophilization: the shift toward plastic press-fit closures enabling streamlined cycles and direct in-chamber capping. The Pharma Days, Geneva, 27 May.

• 2024

  Systematic development and technology transfer in lyophilization. The Pharma Days, Geneva, 5 June.

• 2017

  Risk management approach for transfer of products and processes. ISPE – IPIL Seminar on Externalised Activities, Lyon, France, 10 October.

• 2007

  Chemical modifications of the pore-forming outer membrane protein F (OmpF) aimed at fluorescence studies. Summer School on Transport Across Membranes, Bremen, Germany, 8–14 July.

• 2006

  Different asymmetric pathways to SR 240600 intermediates. University–Sanofi annual meeting, La Londe les Maures, France, 20–21 March.

• 2005

  Syntheses of SR 142801 and SR 240600 intermediates via enantioselective catalyses. University–Sanofi annual meeting, La Londe les Maures, France, 23–24 June.

• 2004

  Syntheses of SR 142801 and SR 240600 precursors by asymmetric catalysis. University–Sanofi annual meeting, La Londe les Maures, France, March.

• 2003

  Asymmetric allylic alkylation: application to the preparation of a pharmaceutical intermediate. Journées Nord Européennes des Jeunes Chercheurs, Lille, France, March.

Poster presentations

• 2015

  QbD key initiative. Bertelsen P., Sato Y., Mittal B., Keldenich J. — Takeda Global CMC Week, Osaka, Japan, 19–23 October.

• 2007

  Cephalothin degradation studies in buffer solutions and DMPC liposomes. Lovelle-Gomez M., Keldenich J., Gameiro P. — Summer School on Transport Across Membranes, Bremen, Germany, 8–14 July.

• 2006

  Asymmetric allylic alkylation applied to the synthesis of a pharmaceutical intermediate. 1st European Chemistry Congress, Budapest, Hungary, 27–31 August.

• 2005

  Asymmetric allylic alkylation: application to the synthesis of a pharmaceutical intermediate. 6th Tetrahedron Symposium, Bordeaux, France, 28 June – 1 July; and 5th International School on Molecular Catalysis, Poznan, Poland, 12–16 August, where it won the poster award.

  Asymmetric allylic alkylation applied to the formation of quaternary stereogenic centers. Recent Advances in Catalysis, Rennes, France, 5–9 September.

  Preparation of a chiral key glutarimide intermediate of SR 142801 via asymmetric allylic alkylation. 9th SFB on Asymmetric Synthesis with Chemical and Biological Methods, Aachen, Germany, 10–11 October.

• 2004

  Asymmetric allylic alkylation: optical purity determination of quaternary centres by 19F NMR. Journées Nord Européennes des Jeunes Chercheurs, Lille, France, March.

Awards and memberships

Poster award, 5th International School on Molecular Catalysis, Poznan, 2005. Travel grant from the Société Française de Chimie for the 1st European Chemistry Congress, Budapest, 2006.

Member of the Parenteral Drug Association and of the International Society of Lyophilization – Freeze Drying.